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CROSS-SECTIONAL IMAGING OF THE LIVER

Computed tomography •   Normal liver is 55-60 HU post-contrast, usually 8-10 HU more than the spleen. •   Most liver tumours are arterialise...

Computed tomography

•  Normal liver is 55-60 HU post-contrast, usually 8-10 HU more than the spleen.
•  Most liver tumours are arterialised and so show maximal enhancement in the arterial phase (20-40 seconds postcontrast).

Magnetic resonance imaging

•  Normal liver returns a signal similar to muscle, except on inversion recovery.
•  On T1, spleen is darker than liver; on T2, spleen is brighter than liver.
•  Gadolinium is the most commonly used contrast agent.
•  Superparamagnetic iron oxide particles shorten T1 and T2 and are taken up by the reticuloendothelial system.
•  Hepatocyte-specific agents (e.g. mangafodipir) accumulate in hepatocytes and are then excreted via the bile—normal liver parenchymal enhancement & biliary system.