1. What is the Dx? A. Rasmussen Encephalitis B. Chronic Ischemic White Matter Disease C. PRES D. CADASIL 2. What is the “C...
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1. What is the Dx?
A. Rasmussen Encephalitis
B. Chronic Ischemic White Matter Disease
C. PRES
D. CADASIL
2. What is the “Classic History” ?
A. Gelastic Seizures
B. Precocious Puberty
C. Migraines
D. Ascending Paralysis
3. White matter involvement where is “Classic” ?
A. It classically spares white matter
B. Temporal Lobes
C. Parietal Lobes
D. Occipital Lobes
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- What is the Dx?
D. CADASIL - What is the “Classic History” ?
C. Migraines - White matter involvement where is “Classic” ?
B. Temporal Lobes
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CADASIL
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy).
Essential Trivia:
- It’s an inherited condition (hence the name). It typically presents between age 30-40.
- The history of migraines (sometimes with aura) is classic. Depression and focal neurologic defects can also occur. For the purpose of multiple choice, I’d go with migraine.
- Lots of things involve the frontal white matter. However, involvement of the temporal white matter -especially when severe in a 30 year old should make you say CADASIL.
- The other classic finding is relative sparing of the occipital subcortical white matter and U-Fibers.
- The MRA is usually normal, with minimal if any atherosclerosis.
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