“ Brain function is normal with isolated callosal agenesis. Partial agenesis always affects the splenium or rostrum (the posterior callosum ...
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Brain function is normal with isolated callosal agenesis. Partial agenesis always affects the splenium or rostrum (the posterior callosum develops last). In total, 60% have developmental anomalies elsewhere in the body and 50% have other neurological anomalies (e.g. holoprosencephaly [not lobar], Chiari II malformation, Dandy-Walker syndrome, encephalocele, etc.).
US
• Can be diagnosed on the 20-week scan
• Colpocephaly ( dilated trigones, occipital horns and posterior temporal horns)
• Absent splenium
• Dilated and elevated third ventricle
MRI
• Lateral ventricles have a ‘steerhorn’ appearance on the coronals.
• Look for an absent cavum septum pellucidum/cingulate gyrus, high-riding third ventricle and colpocephaly.
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