“ This is a haemolytic anaemia resulting from the presence of abnormal b-globin chains within haemoglobin. Musculoskeletal abnormalities may...
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This is a haemolytic anaemia resulting from the presence of abnormal b-globin chains within haemoglobin. Musculoskeletal abnormalities may be due to the effects of chronic anaemia (e.g. marrow proliferation/reconversion, extramedullary haematopoiesis or bone softening/infarction) or infection (up to 70% due to Salmonella).
APPENDICULAR X-RAY
• Osteopenia and coarsening of the trabeculae
• ‘Bone in bone’ appearance due to infarctions
• AVN
CHEST X-RAY
• Rib thinning with notching.
• Check the humeral heads for AVN.
• H-shaped (‘cod fish’) vertebrae due to central vertebral endplate infarction.
SKULL X-RAY
• Skull—widening of the diploe with ‘hair on end’ striations
NUCLEAR MEDICINE
• Decreased uptake on bone marrow scan, although uptake is increased after collateralisation.
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