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CRYPTOGENIC ORGANISING PNEUMONIA (COP)

“ Previously known as bronchiolitis obliterans organising pneumonia. It is characterised by the onset of cough, dyspnoea and low-grade pyre...

Previously known as bronchiolitis obliterans organising pneumonia. It is characterised by the onset of cough, dyspnoea and low-grade pyrexia over several weeks. Wide age range affected, more common between 40 and 70 years of age.
Plain film
•  Bilateral, peripheral patchy consolidation.
•  Fleeting/migratory consolidation is classic.
HRCT

•  Typically multifocal, transient, patchy, dense consolidation with a predominantly sub-pleural, midlower zone distribution (80%).
•  Small centrilobular nodules and peribronchial thickening.
•  The ‘atoll’ sign is characteristic (not pathognomic), lesion with central ground glass and rim of consolidation.
•  Adenopathy (25%) and effusions (30%) are less common.
•  Dense consolidation helps to distinguish COP from desquamative interstitial pneumonia (DIP)— ground-glass opacification dominates in DIP