“ Autoimmune disease characterised by glomerulonephritis and pulmonary haemorrhage —note that pulmonary features occur before renal manifest...
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Autoimmune disease characterised by glomerulonephritis and pulmonary haemorrhage—note that pulmonary features occur before renal manifestations. The pathology is antiglomerular basement membrane antibodies; these attack the alveolar basement membrane in the lung. Associated with a positive p-ANCA (anti-neutrophil cytoplasmic antibody) or c-ANCA in about 30%.
PLAIN FILM
• Bilateral consolidation with sparing of the costophrenic angles and lung periphery.
• Progression to an interstitial/fibrotic pattern in chronic disease.
HRCT
• Patchy ground-glass opacification with peripheral and costophrenic angle sparing.
• Airspace disease clears within a couple of weeks.
• Pulmonary fibrosis may develop in the long term.
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