Increased triglyceride loading of hepatocytes due to excess alcohol, obesity, diabetes, CF, malnutrition, total parenteral nutrition, drugs ...
Increased triglyceride loading of hepatocytes due to excess alcohol, obesity, diabetes, CF, malnutrition, total parenteral nutrition, drugs (steroids, methotrexate, chemotherapy and amiodarone), hepatitis or pregnancy. The stages are:
1. Steatosis (common, affects 15% of the population)
2. Non-alcoholic steatohepatitis (NASH) (6%-8% progress to this)
3. Cirrhosis (15% progress to cirrhosis)
US
• Diffusely hyper-reflective liver—adjacent renal cortex is hypo-reflective compared to the adjacent liver (the reflectivity is normally similar).• Loss of definition of the diaphragm.• Poor visualisation of the intrahepatic architecture.
CT
• Liver is diffusely hypodense—eventually, hepatic vessels look as if they contain contrast when they do not.• Density of <40 HU is diagnostic.• Density >10 HU less than that of the spleen on an unenhanced scan.
MRI
• In- and out-of-phase imaging is best for diagnosis: there is loss of signal on out-of-phase imaging compared to in-phase imaging.• Increased signal on T1 and mildly so on T2.• Low signal on STIR.
”
- For Radiology Cases, Discussion join: Radiology Made Easy on Facebook
- Subscribe to our youtube channel for FRCR radiology case discussion
- Join our Telegram group: Radiology Made Easy
