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SCHIZENCEPHALY

“ Abnormal cleft lined with polymicrogyric grey matter linking the pial and ependymal surfaces. May communicate openly with the ventricular ...

Abnormal cleft lined with polymicrogyric grey matter linking the pial and ependymal surfaces. May communicate openly with the ventricular system. In total, 90% have an absent septum pellucidum. Linked to polymicrogyria and septo-optic dysplasia.
MRI

•  Cleft lined by grey matter; if there is CSF in the cleft it is known as ‘open lipped’, if there is not it is ‘close lipped’.
•  Note: A porencephalic cleft (i.e. old hypoxic ischaemic injury [HII]) can appear similar but is lined by white matter.