“ The UIP pattern is seen with idiopathic pulmonary fibrosis (IPF; the clinical syndrome). It typically affects those >50 years of ag e,...
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The UIP pattern is seen with idiopathic pulmonary fibrosis (IPF; the clinical syndrome). It typically affects those >50 years of age, often with a smoking history. The UIP pattern is also seen with rheumatoid lung, systemic sclerosis (can have UIP or non-specific interstitial pneumonia [NSIP] pattern), asbestosis and other connective tissue diseases. Response to steroids and prognosis is poor in IPF.
Plain film
• Normal at first, then decreased lung volumes with sub-pleural, basal reticulation.
HRCT
• The classic trio is:
(1) apicobasal gradient of(2) sub-pleural reticular opacities, and(3) macrocystic honeycombing and traction bronchiectasis.
• Ground-glass attenuation less extensive than the reticular opacities.
• Check for an irregular pleural surface.
• Typically, abnormal lung is seen next to normal lung.
• The pattern is typical, biopsy may not be required for diagnosis.
• 10% of IPF patients develop lung cancer.
• Check for an irregular pleural surface.
• Typically, abnormal lung is seen next to normal lung.
• The pattern is typical, biopsy may not be required for diagnosis.
• 10% of IPF patients develop lung cancer.
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