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"GRAVE DISEASE"

“ This is an autoimmune disease associated with human leukocyte antigen (HLA) antibodies.  Typically, it presents with thyrotoxicosis, goitr...

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This is an autoimmune disease associated with human leukocyte antigen (HLA) antibodies. 
Typically, it presents with thyrotoxicosis, goitre and eye disease (bilateral enlargement of the extraocular muscles).
US

•  Enlarged gland, heterogeneous echotexture with spotty hypoechoic appearance
•  Marked hyperaemia—‘thyroid inferno’

CT/MRI

•  Useful for establishing a diagnosis of thyroid associated ophthalmopathy.
•  Enlargement of the extraocular muscles with sparing of the tendon insertions: muscles most commonly affected are inferior > medial > superior > lateral > oblique (mnemonic = ‘I’M SLO’).
•  May only involve the retrobulbar fat.


NUCLEAR MEDICINE

•  Uniform increased uptake
•  Elevated iodine uptake in up to 80%

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