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"GRAVE DISEASE"

“ This is an autoimmune disease associated with human leukocyte antigen (HLA) antibodies.  Typically, it presents with thyrotoxicosis, goitr...

This is an autoimmune disease associated with human leukocyte antigen (HLA) antibodies. 
Typically, it presents with thyrotoxicosis, goitre and eye disease (bilateral enlargement of the extraocular muscles).
US

•  Enlarged gland, heterogeneous echotexture with spotty hypoechoic appearance
•  Marked hyperaemia—‘thyroid inferno’

CT/MRI

•  Useful for establishing a diagnosis of thyroid associated ophthalmopathy.
•  Enlargement of the extraocular muscles with sparing of the tendon insertions: muscles most commonly affected are inferior > medial > superior > lateral > oblique (mnemonic = ‘I’M SLO’).
•  May only involve the retrobulbar fat.


NUCLEAR MEDICINE

•  Uniform increased uptake
•  Elevated iodine uptake in up to 80%