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"HYPOXIC ISCHAEMIC INJURY IN INFANCY"

“ After about 2 years of age, the pattern of injury is the same as that seen in an adult. There is relative sparing of the thalamic nuclei f...

After about 2 years of age, the pattern of injury is the same as that seen in an adult. There is relative sparing of the thalamic nuclei from ages 1-2 years. The corpora striata, hippocampi and cortex are most affected.
CT

 Bilateral low-density basal ganglia, cerebral oedema.
•  Occasionally, there is reversal of the normal pattern of grey and white matter attenuation (white matter appears more dense than the grey matter)—the ‘reversal sign’.
•  Diffuse cortical oedema with sparing of the cerebellum causes the ‘white cerebellum sign’.

MRI

•  DWI most sensitive acutely, usually abnormal by 24 hours
•  T2 abnormalities appear by 2 days