This is due to haemosiderin deposition (mostly in the reticuloendothelial system), associated with repeated blood transfusions. There is iro...
This is due to haemosiderin deposition (mostly in the reticuloendothelial system), associated with repeated blood transfusions. There is iron deposition without organ dysfunction mostly in the liver, spleen and bone marrow.
CT
• Liver density is >75 HU, greater than expected (usually 55-60 HU).
MRI
• Low signal T1, T2 and T2* in the liver and spleen—the pancreas is spared.
• Best demonstrated by signal loss on T2* gradient echo sequences (GRE)—the more iron there is, the more signal is lost.
• The spleen is usually less infiltrated than the liver (therefore brighter on MRI).
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